{"id":1759,"date":"2020-12-14T15:31:47","date_gmt":"2020-12-14T08:31:47","guid":{"rendered":"https:\/\/benhvienvietbi.vn\/en\/?p=1759"},"modified":"2024-07-04T15:01:56","modified_gmt":"2024-07-04T08:01:56","slug":"tiem-tinh-trung-vao-bao-tuong-noan-icsi-va-phuong-phap-hoat-hoa-noan-nhan-tao-aoa","status":"publish","type":"post","link":"https:\/\/benhvienvietbi.vn\/en\/tiem-tinh-trung-vao-bao-tuong-noan-icsi-va-phuong-phap-hoat-hoa-noan-nhan-tao-aoa\/","title":{"rendered":"TI\u00caM TINH TR\u00d9NG V\u00c0O B\u00c0O T\u01af\u01a0NG NO\u00c3N ( ICSI ) V\u00c0 PH\u01af\u01a0NG PH\u00c1P HO\u1ea0T H\u00d3A NO\u00c3N NH\u00c2N T\u1ea0O ( AOA)"},"content":{"rendered":"\n

Hi\u1ec7n nay, \u1edf ph\u1ea7n l\u1edbn c\u00e1c n\u01b0\u1edbc ph\u00e1t tri\u1ec3n v\u00e0 \u0111ang ph\u00e1t tri\u1ec3n, 5 \u2013 7% c\u00e1c c\u1eb7p v\u1ee3 ch\u1ed3ng ph\u1ea3i t\u00ecm \u0111\u1ebfn s\u1ef1 gi\u00fap \u0111\u1ee1 t\u1eeb c\u00e1c k\u1ef9 thu\u1eadt h\u1ed7 tr\u1ee3 sinh s\u1ea3n. Trong \u0111\u00f3, k\u1ef9 thu\u1eadt th\u1ee5 tinh trong \u1ed1ng nghi\u1ec7m (TTTON) c\u1ed5 \u0111i\u1ec3n \u0111\u01b0\u1ee3c xem l\u00e0 k\u1ef9 thu\u1eadt \u0111em l\u1ea1i hi\u1ec7u qu\u1ea3 th\u00e0nh c\u00f4ng cao nh\u1ea5t \u0111\u1ed1i v\u1edbi c\u00e1c c\u1eb7p v\u1ee3 ch\u1ed3ng hi\u1ebfm mu\u1ed9n \u2013 v\u00f4 sinh. Tuy nhi\u00ean, k\u1ef9 thu\u1eadt n\u00e0y c\u0169ng tr\u1edf n\u00ean b\u1ea5t l\u1ef1c tr\u01b0\u1edbc nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng tr\u01b0\u1eddng h\u1ee3p v\u00f4 sinh do tinh tr\u00f9ng y\u1ebfu n\u1eb7ng. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y, tinh tr\u00f9ng kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng xuy\u00ean qua m\u00e0ng trong su\u1ed1t c\u1ee7a no\u00e3n, do \u0111\u00f3, k\u1ef9 thu\u1eadt ti\u00eam tinh tr\u00f9ng v\u00e0o b\u00e0o t\u01b0\u01a1ng no\u00e3n (ICSI \u2013 intracytoplasmic sperm injection) \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng \u0111\u1ec3 gi\u1ea3i quy\u1ebft v\u1ea5n \u0111\u1ec1 n\u00e0y.<\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

Chu k\u1ef3 \u0111i\u1ec1u tr\u1ecb\nICSI c\u1ee7a b\u1ea1n ho\u00e0n to\u00e0n gi\u1ed1ng v\u1edbi IVF th\u00f4ng th\u01b0\u1eddng. S\u1ef1 kh\u00e1c bi\u1ec7t duy nh\u1ea5t\nl\u00e0 c\u00e1c nh\u00e0 ph\u00f4i h\u1ecdc c\u1ee7a ch\u00fang t\u00f4i s\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt vi m\u00f4 trong ph\u00f2ng th\u00ed nghi\u1ec7m\n\u0111\u1ec3 th\u1ee5 tinh cho tr\u1ee9ng c\u1ee7a b\u1ea1n, thay v\u00ec \u0111\u1eb7t tinh tr\u00f9ng v\u00e0 tr\u1ee9ng c\u00f9ng nhau trong\nm\u1ed9t \u0111\u0129a nu\u00f4i c\u1ea5y m\u00f4.<\/p>\n\n\n\n

Ti\u00eam tinh tr\u00f9ng v\u00e0o t\u1ebf b\u00e0o ch\u1ea5t (ICSI) l\u00e0 m\u1ed9t k\u1ef9 thu\u1eadt ph\u00f2ng th\u00ed nghi\u1ec7m c\u00f3 th\u1ec3 ph\u00f9 h\u1ee3p v\u1edbi b\u1ea1n n\u1ebfu tinh tr\u00f9ng c\u1ee7a b\u1ea1n c\u1ea7n th\u00eam m\u1ed9t ch\u00fat tr\u1ee3 gi\u00fap \u0111\u1ec3 th\u1ee5 tinh th\u00e0nh c\u00f4ng.\u00a0Ph\u00f4i \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1eb1ng k\u1ef9 thu\u1eadt ICSI s\u1ebd \u0111\u01b0\u1ee3c chuy\u1ec3n gi\u1ed1ng h\u1ec7t nh\u01b0 trong IVF ti\u00eau chu\u1ea9n. <\/p>\n\n\n\n

\"\"<\/figure><\/div>\n\n\n\n

Tr\u1ee9ng \u0111\u01b0\u1ee3c thu th\u1eadp theo c\u00e1ch t\u01b0\u01a1ng t\u1ef1 nh\u01b0 IVF v\u00e0 m\u1ed9t tinh tr\u00f9ng \u0111\u01b0\u1ee3c ti\u00eam v\u00e0o trung t\u00e2m c\u1ee7a m\u1ed7i tr\u1ee9ng tr\u01b0\u1edfng th\u00e0nh \u0111\u1ec3 h\u1ed7 tr\u1ee3 qu\u00e1 tr\u00ecnh th\u1ee5 tinh trong ph\u00f2ng th\u00ed nghi\u1ec7m.\u00a0Ch\u00fang t\u00f4i s\u1eed d\u1ee5ng ICSI k\u1ebft h\u1ee3p v\u1edbi chu k\u1ef3 IVF khi ch\u00fang t\u00f4i tin r\u1eb1ng vi\u1ec7c th\u1ee5 tinh kh\u00f3 c\u00f3 th\u1ec3 x\u1ea3y ra khi s\u1eed d\u1ee5ng IVF th\u00f4ng th\u01b0\u1eddng.<\/p>\n\n\n\n

T\u01b0\u01a1ng t\u1ef1 nh\u01b0 chu k\u1ef3 th\u1ee5 tinh \u1ed1ng nghi\u1ec7m th\u00f4ng th\u01b0\u1eddng, m\u1ed9t ho\u1eb7c hai ph\u00f4i k\u1ebft qu\u1ea3 sau \u0111\u00f3 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c chuy\u1ec3n v\u00e0o t\u1eed cung v\u00e0 b\u1ea5t k\u1ef3 ph\u00f4i n\u00e0o ph\u00f9 h\u1ee3p b\u1ed5 sung c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111\u00f4ng l\u1ea1nh \u0111\u1ec3 s\u1eed d\u1ee5ng trong t\u01b0\u01a1ng lai.<\/p>\n\n\n\n

B\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb c\u00f3 th\u1ec3 \u0111\u1ec1 xu\u1ea5t ICSI khi:<\/p>\n\n\n\n

– S\u1ed1 l\u01b0\u1ee3ng tinh tr\u00f9ng c\u1ee7a b\u1ea1n th\u1ea5p<\/p>\n\n\n\n

– Kh\u1ea3 n\u0103ng di chuy\u1ec3n c\u1ee7a tinh tr\u00f9ng – chuy\u1ec3n \u0111\u1ed9ng – k\u00e9m<\/p>\n\n\n\n

– B\u1ea1n c\u00f3 s\u1ed1 l\u01b0\u1ee3ng tinh tr\u00f9ng b\u1ea5t th\u01b0\u1eddng cao<\/p>\n\n\n\n

– Tinh tr\u00f9ng c\u1ee7a b\u1ea1n \u0111\u00e3 \u0111\u01b0\u1ee3c l\u1ea5y b\u1eb1ng ph\u1eabu thu\u1eadt<\/p>\n\n\n\n

– Tinh d\u1ecbch c\u1ee7a b\u1ea1n c\u00f3 ch\u1ee9a l\u01b0\u1ee3ng kh\u00e1ng th\u1ec3<\/p>\n\n\n\n

– B\u1ea1n \u0111\u00e3 t\u1eebng \u0111i\u1ec1u tr\u1ecb IVF th\u00f4ng th\u01b0\u1eddng, kh\u00f4ng gi\u1ea3i th\u00edch \u0111\u01b0\u1ee3c, kh\u00f4ng th\u00e0nh c\u00f4ng ho\u1eb7c khi r\u1ea5t \u00edt tr\u1ee9ng \u0111\u00e3 th\u1ee5 tinh sau IVF<\/p>\n\n\n\n

– C\u00e1c x\u00e9t nghi\u1ec7m v\u1ec1 ch\u1ee9c n\u0103ng tinh tr\u00f9ng c\u1ee7a b\u1ea1n \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng tinh tr\u00f9ng kh\u00f3 c\u00f3 th\u1ec3 th\u1ee5 tinh ho\u1eb7c ch\u1ea5t l\u01b0\u1ee3ng ph\u00f4i v\u00e0 qu\u00e1 tr\u00ecnh c\u1ea5y gh\u00e9p c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng<\/p>\n\n\n\n

– B\u1ea1n \u0111\u00e3 ch\u1ecdn s\u1eed d\u1ee5ng tr\u1ee9ng v\u00e0 tinh tr\u00f9ng hi\u1ebfn t\u1eb7ng<\/p>\n\n\n\n

Tuy nhi\u00ean, d\u00f9 c\u00f3\ns\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a k\u1ef9 thu\u1eadt ICSI nh\u01b0ng t\u1ef7 l\u1ec7 th\u1ea5t b\u1ea1i th\u1ee5 tinh ho\u00e0n to\u00e0n c\u1ee7a c\u00e1c\nchu k\u1ef3 th\u1ee5 tinh trong \u1ed1ng nghi\u1ec7m v\u1eabn c\u00f2n kho\u1ea3ng 1-5%. Vi\u1ec7c k\u1ebft h\u1ee3p gi\u1eefa k\u1ef9 thu\u1eadt\nICSI v\u00e0 ho\u1ea1t h\u00f3a no\u00e3n nh\u00e2n t\u1ea1o (AOA) c\u00f3 th\u1ec3 coi l\u00e0 ph\u01b0\u01a1ng ph\u00e1p c\u1ee9u c\u00e1nh. <\/p>\n\n\n\n

\u0110\u1ed1i v\u1edbi nh\u1eefng tr\u01b0\u1eddng\nh\u1ee3p no\u00e3n kh\u00f4ng c\u00f3 hi\u1ec7n t\u01b0\u1ee3ng th\u1ee5 tinh sau khi ti\u00eam tinh tr\u00f9ng do th\u1ea5t b\u1ea1i trong\nqu\u00e1 tr\u00ecnh ho\u1ea1t h\u00f3a no\u00e3n, ng\u01b0\u1eddi ta \u0111\u00e3 ngh\u0129 \u0111\u1ebfn c\u00e1ch kh\u1edfi \u0111\u1ed9ng qu\u00e1 tr\u00ecnh n\u00e0y m\u1ed9t\nc\u00e1ch nh\u00e2n t\u1ea1o. Nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p ho\u1ea1t h\u00f3a no\u00e3n nh\u00e2n t\u1ea1o (AOA\u2013 artificial oocyte\nactivation) kh\u00e1c nhau \u0111\u00e3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng t\u1ea1i nhi\u1ec1u trung t\u00e2m TTTON tr\u00ean th\u1ebf gi\u1edbi.<\/p>\n\n\n\n

\u00a0Hai ph\u01b0\u01a1ng ph\u00e1p AOA \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn nhi\u1ec1u nh\u1ea5t hi\u1ec7n nay l\u00e0 AOA b\u1eb1ng d\u00f2ng \u0111i\u1ec7n v\u00e0 AOA h\u00f3a h\u1ecdc. V\u1edbi ph\u01b0\u01a1ng ph\u00e1p AOA b\u1eb1ng d\u00f2ng \u0111i\u1ec7n, m\u1ed9t d\u00f2ng \u0111i\u1ec7n r\u1ea5t nh\u1ecf \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 k\u00edch th\u00edch no\u00e3n sau ICSI, \u0111i\u1ec7n tr\u01b0\u1eddng s\u1ebd t\u1ea1o th\u00e0nh nh\u1eefng l\u1ed7 nh\u1ecf tr\u00ean m\u00e0ng b\u00e0o t\u01b0\u01a1ng no\u00e3n v\u00e0 nh\u1edd \u0111\u00f3 s\u1ebd k\u00edch th\u00edch t\u1ea1o d\u00f2ng Ca2+ b\u00ean trong no\u00e3n. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y t\u1eebng \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng th\u00e0nh c\u00f4ng tr\u00ean no\u00e3n b\u00f2 v\u00e0 no\u00e3n ng\u01b0\u1eddi.<\/p>\n\n\n\n

V\u1edbi ph\u01b0\u01a1ng ph\u00e1p AOA h\u00f3a h\u1ecdc, nh\u1eefng h\u1ee3p ch\u1ea5t h\u00f3a h\u1ecdc (nh\u01b0 calcium ionophore A213187, ionomycin,purimycin, strontium chloride,\u2026) c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 t\u1ea1o ra s\u1ef1 gia t\u0103ng n\u1ed3ng \u0111\u1ed9 Ca2+ v\u00e0 kh\u1edfi \u0111\u1ed9ng ph\u1ea3n \u1ee9ng ho\u1ea1t h\u00f3a no\u00e3n. Nh\u1eefng th\u00e0nh ph\u1ea7n n\u00e0y s\u1ebd x\u00fac ti\u1ebfn s\u1ef1 gi\u1ea3i ph\u00f3ng Ca2+ n\u1ed9i b\u00e0o t\u1eeb c\u00e1c ngu\u1ed3n d\u1ef1 tr\u1eef c\u1ee7a t\u1ebf b\u00e0o cho \u0111\u1ebfn khi c\u1ea1n, \u0111i\u1ec1u n\u00e0y s\u1ebd t\u1ea1o thu\u1eadn l\u1ee3i cho Ca2+ ngo\u1ea1i b\u00e0o tr\u00e0n v\u00e0o. Nh\u1edd \u0111\u00f3 m\u00e0 n\u1ed3ng \u0111\u1ed9 Ca2+ b\u00ean trong t\u1ebf b\u00e0o t\u0103ng l\u00ean,v\u00e0 k\u1ebft qu\u1ea3 l\u00e0 ho\u1ea1t h\u00f3a no\u00e3n x\u1ea3y ra.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

T\u1ea1i Vi\u1ec7t Nam, k\u1ef9 thu\u1eadt ICSI \u0111\u00e3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng th\u00e0nh c\u00f4ng t\u1eeb n\u0103m 1998. Hi\u1ec7n nay, ICSI \u0111\u00e3 tr\u1edf th\u00e0nh k\u1ef9 thu\u1eadt th\u01b0\u1eddng quy v\u00e0 ph\u1ed5 bi\u1ebfn t\u1ea1i t\u1ea5t c\u1ea3 c\u00e1c trung t\u00e2m TTTON \u1edf Vi\u1ec7t Nam. Ri\u00eang v\u1edbi AOA, B\u1ec7nh vi\u1ec7n chuy\u00ean khoa Nam h\u1ecdc v\u00e0 Hi\u1ebfm mu\u1ed9n Vi\u1ec7t – B\u1ec9 \u0111\u00e3 b\u1eaft \u0111\u1ea7u \u00e1p d\u1ee5ng AOA cho m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p tinh tr\u00f9ng b\u1ea5t th\u01b0\u1eddng ho\u00e0n to\u00e0n d\u1ea1ng \u0111\u1ea7u tr\u00f2n v\u00e0 b\u1ea5t \u0111\u1ed9ng to\u00e0n b\u1ed9 cho k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb kh\u1ea3 quan, \u0111em l\u1ea1i nhi\u1ec1u hy v\u1ecdng h\u01a1n cho nh\u1eefng gia \u0111\u00ecnh hi\u1ebfm mu\u1ed9n. <\/p>\n","protected":false},"excerpt":{"rendered":"

Hi\u1ec7n nay, k\u1ef9 thu\u1eadt th\u1ee5 tinh trong \u1ed1ng nghi\u1ec7m (TTTON) c\u1ed5 \u0111i\u1ec3n \u0111\u01b0\u1ee3c xem l\u00e0 k\u1ef9 thu\u1eadt \u0111em l\u1ea1i hi\u1ec7u qu\u1ea3 th\u00e0nh c\u00f4ng cao nh\u1ea5t \u0111\u1ed1i v\u1edbi c\u00e1c c\u1eb7p v\u1ee3 ch\u1ed3ng hi\u1ebfm mu\u1ed9n\u2013 v\u00f4 sinh. Tuy nhi\u00ean, k\u1ef9 thu\u1eadt n\u00e0y c\u0169ng tr\u1edf n\u00ean b\u1ea5t l\u1ef1c tr\u01b0\u1edbc nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng tr\u01b0\u1eddng h\u1ee3p v\u00f4 sinh do tinh tr\u00f9ng y\u1ebfu n\u1eb7ng. \u1ede nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y, tinh tr\u00f9ng kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng xuy\u00ean qua m\u00e0ng trong su\u1ed1t c\u1ee7a no\u00e3n, do \u0111\u00f3, k\u1ef9 thu\u1eadt ti\u00eam tinh tr\u00f9ng v\u00e0o b\u00e0o t\u01b0\u01a1ng no\u00e3n (ICSI \u2013 intracytoplasmic sperm injection) \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng \u0111\u1ec3 gi\u1ea3i quy\u1ebft v\u1ea5n \u0111\u1ec1 n\u00e0y.<\/p>\n","protected":false},"author":3,"featured_media":1761,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[365,368,383,21,101,22],"tags":[],"class_list":["post-1759","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dich-vu","category-dich-vu-ho-tro-sinh-san","category-dich-vu-tiem-tinh-trung-vao-bao-tuong-noan-icsi","category-gioi-thieu-ve-benh-vien","category-ky-thuat-ho-tro-sinh-san","category-vo-sinh-hiem-muon"],"acf":[],"yoast_head":"\nTI\u00caM TINH TR\u00d9NG V\u00c0O B\u00c0O T\u01af\u01a0NG NO\u00c3N ( ICSI ) V\u00c0 PH\u01af\u01a0NG PH\u00c1P HO\u1ea0T H\u00d3A NO\u00c3N NH\u00c2N T\u1ea0O ( AOA) - VIET \u2013 BI SPECIALIZED HOSPITAL IN ANDROLOGY AND INFERTILITY<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/benhvienvietbi.vn\/en\/tiem-tinh-trung-vao-bao-tuong-noan-icsi-va-phuong-phap-hoat-hoa-noan-nhan-tao-aoa\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TI\u00caM TINH TR\u00d9NG V\u00c0O B\u00c0O T\u01af\u01a0NG NO\u00c3N ( ICSI ) V\u00c0 PH\u01af\u01a0NG PH\u00c1P HO\u1ea0T H\u00d3A NO\u00c3N NH\u00c2N T\u1ea0O ( AOA) - VIET \u2013 BI SPECIALIZED HOSPITAL IN ANDROLOGY AND INFERTILITY\" \/>\n<meta property=\"og:description\" content=\"Hi\u1ec7n nay, k\u1ef9 thu\u1eadt th\u1ee5 tinh trong \u1ed1ng nghi\u1ec7m (TTTON) c\u1ed5 \u0111i\u1ec3n \u0111\u01b0\u1ee3c xem l\u00e0 k\u1ef9 thu\u1eadt \u0111em l\u1ea1i hi\u1ec7u qu\u1ea3 th\u00e0nh c\u00f4ng cao nh\u1ea5t \u0111\u1ed1i v\u1edbi c\u00e1c c\u1eb7p v\u1ee3 ch\u1ed3ng hi\u1ebfm mu\u1ed9n\u2013 v\u00f4 sinh. 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